Infectious information

Words and virus particles are both infectious units of information that depend on human vehicles for transport. Their flows are often correlated too, since a quarantine on words can cause an outbreak of virus. The Spanish flu flared so spectacularly in part because no one was willing to talk about it; wartime censorship locked down information about the disease. The very name Spanish flu came about because the neutral Spaniards were the only ones willing to talk about it in their relatively unfettered newspapers. In the honored tradition of shooting messengers, whoever comes forward to announce a disease is forever linked to it by name. Or, as we used to say in high school, the smeller is the feller.

The phrase Spanish influenza still sounds chilling to my ear. Our latest flu may or may not be on so destructive a course, but in terms of pure poetry, which sounds most menacing: Mexican flu, swine flu, or H1N1? This last one, H1N1, has the sinister sound of a science fiction villain, but I prefer it. Its name is based not on origin but on content. Since it describes the actual nature of the virus, it gives me a certain semantic power that the dark image of a rooting pig does not. Semantic power may not prevent you from getting sick, but it can inoculate you against the formidable informational aspects of the flu: dread and panic. As these spread more quickly and widely than the flu itself, this data vaccine should not be lightly dismissed.

H1N1 is a shorthand that, like a Mafia nickname, both describes and identifies. Fat Tony. Frankie the Beard. “Big Cough” Fluey. If you were a lung cell, you would see H1N1 coming and recognize him by his fancy coat, a protein coat studded with hemagglutinin subtype 1 (H1) and neuraminidase subtype 1 (N1).

To underscore the informational nature of viruses, here’s the genome: GenBank sequences from 2009 H1N1 influenza outbreak. It’s all there. Need some virus? Ask a DNA synthesis vendor (like Mr. Gene) to print some up for you. Should we suppress the NIH web site that tells you how to make H1N1? Or would that merely encourage the wild publication of the virus inside human rib cages around the world? It’s a complex game of information trade-offs, but one thing’s for sure. We’re better off now than we were in 1918.

Crohn Banished by Diet of Worms

Your body evolved in an environment that was vastly filthier than the one you now inhabit. As a result, living with all this good hygiene can actually cause real problems in cases where your body has come to depend on filth. Your gut expects to manage large numbers of parasitic whipworms, for example, and, for the sophisticated readers of this weblog anyway, this just isn’t the case. For people with inflammatory bowel diseases (IBDs), like Crohn’s disease, the gut is violently wrestling with an opponent that never showed up. Or that’s the theory proposed by gastroenterologist Joel Weinstock.

Weinstock had a brilliantly testable idea: feed IBD sufferers a diet of worms. The clinical results, as reported in this New Scientist article, are nothing short of astonishing. Seventy of the hundred Crohn’s sufferers in the study experienced complete remission of the symptoms. If this all holds up, you will soon be able to order a “drinkable concoction containing thousands of pig whipworm eggs” (this from the same company, no lie, that brings you quality medicinal maggots and leeches).

I sense an exciting new high-concept juice bar business opportunity. The “Old McDonald” will be a lightly frothed blend of wheat grass and pig whipworms that can be spooned right out of the barnyard.