Dodgy dogma and biology

Dogma is a funny word to appear so prominently in a science like biology. Any picture, any model, any theory currently in vogue is resting on the shifting sands of biological weirdness. I love, for instance, the fact that the Nobel Prize in medicine this year was awarded for major form of genetic regulation that nobody knew existed eight years ago.

A few weeks ago after I posted a link to some lovely molecular biology animations, my good friend Mike Onken made a comment that contained an oblique but cutting reference to the so-called Central Dogma of molecular biology. Since Mike is a certified Level 50 Molecular Biology Warlock at Washington University in St. Louis, I knew there was a good story behind that remark. I hounded him until he gave it up. “Everybody loves the Central Dogma,” I intoned. “It’s so dogmatic, and quasi-religious certainty is very sexy these days. What have you got against it?”

I got the response I was looking for, which I happily share below. Please allow me to present the words of Mike Onken:
Continue reading “Dodgy dogma and biology”

The Last Tree of Ténéré

Look at this satellite view of central Niger. Zoom out, and then zoom out some more, and you’ll eventually see that you’re staring at a vast expanse of the trackless and empty Sahara. Except for this historical footnote: at the very center of this map stood, for several decades, a single tree, as well known by the desert-crossing caravans as an island would be in the middle of the Pacific.

I came across the heartbreaking story of the Last Tree of Ténéré while visiting the estimable Athanasius Kircher Society. Here’s what they had to say there.

The Ténéré wastelands of northeastern Niger were once populated by a forest of trees. By the 20th century, desertification had wiped out all but one solitary acacia. [It] had no companions for 400 km in every direction. Its roots reached nearly 40 m deep into the sand. In 1973, the tree was knocked over by a drunken Libyan truck driver. It has been replaced by a simple metal sculpture.

What a story! A desperately poignant one-tree recapitulation of Jared Diamond’s Collapse thesis. Diamond tells in his book how, some time around 1680, the Easter Islanders chopped down the last of the great palm trees that once covered the island. And he poses the rhetorical question: “What did they say as they chopped down the last palm tree?” Which makes me wonder what our friend the truck driver said on that fateful day in 1973.

Was it: “Oh great! I got the whole freakin’ Sahara and somebody puts a tree right in front of my truck! Now I’m gonna be late for poker night.” Or maybe: “Dude, I am so wasted…” Or my favorite: “Hey, watch this!”

Jesus in the operating room

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The Boston Globe did a story yesterday called Healing the Body to Reach the Soul. It’s part of a series on faith-based initiatives called “Exporting Faith.” On the front page it had this picture, taken from a brochure published by a non-denominational Christian organization, of Jesus guiding the hand of a surgeon in the operating room. Without addressing any of the touchy political or religious implications of an image like this, I think that there is no disputing that this is a darn funny image. I confess to adding the speech balloon above the surgeon’s head, because the picture just begs to be part of a caption contest. First I thought, what would Jesus be saying in a situation like this? But then I thought, no, the real humor is going on in the surgeon’s head. What’s he saying?

“Are your hands clean? Because they look filthy.”

“I’m just saying, we’re only one quick miracle away from two martinis in the surgeon’s lounge.”

You tell me what he’s saying.

Raising money for autism research

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Every fall, my family participates in a fund-raising walk to support autism research. My seven year old son Jay is severely autistic and unable to talk. When we tell people he can’t talk, they often assume that he must still understand things fairly well, but this is not the case. Sometimes I want to explain that Jay has no language, but this is a hard concept to get across quickly. In a practical sense, it means Jay is profoundly apart from the rest of us, and likely always will be. The good news is that, as far as we can tell, Jay doesn’t suffer any mental anguish as a result of his separation. He’s generally a pretty happy kid. His parents had to mourn the passing of the child they thought Jay was. This caused real pain, but crucially this child that did pass away wasn’t Jay. He was a fiction, a projection of the hope that imagines the future can be predicted. When you look into a child’s eyes, what do you see? It’s hard to see the child, so often cloaked by heavy layers of expectation and projection. That is one gift Jay has given me: I have learned the importance of seeing Jay when I look at Jay. It’s a hard lesson to learn.

Dealing with Jay has taught me many valuable lessons, but all the same, I’d rather that you never have to confront autism in your own family. Unless we can understand more about how and why autism happens, there is the increasing and disturbing possibility that you will encounter it in your extended family some day. Research is the only way forward, and research costs money. That’s why I’m asking for your support. Go to the “Walk for Autism” web site and pledge some money for our walk. I’ll thank you right now for doing it.

I am also including below my wife’s annual fund-raising letter.
Continue reading “Raising money for autism research”

HP photo slimming

I need your help on this one. Is this a feature or a terrible omen for our deranged times? HP has introduced a digital camera effect called the slimming feature. Here’s their ad copy on the topic.

They say cameras add ten pounds, but HP digital cameras can help reverse that effect. The slimming feature, available on select HP digital camera models, is a subtle effect that can instantly trim off pounds from the subjects in your photos!

When I saw someone had linked to this from a blog I was reading, I was convinced it was a fake. I kept looking at the HP URL trying to work out if it was a hacked address of some kind. But no, this is a real feature on real cameras. I can’t figure out if I’m off base being astonished by this. I’ve talked to people who can’t figure out why I find this so disturbing. I guess slimming your photo is better than sticking your finger down your throat after brunch, but it seems dishonest in some very damaging ways.

If it takes off in the marketplace, though, I’m thinking about selling a JolieCam. It’s a camera that, no matter who you point it at (your dog, your grandma, your half-eaten tuna sandwich), always spits out a glamorous photo of Angelina Jolie. Why look frumpy when you can look vampy?

So what’s your verdict on the slimming feature: funny harmless feature, or one more sign that the apocalypse is near?

Stellarium stargazing software

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I’ve been on a good run with free software lately. As part of some recent work I’ve been doing with my Sky Clock, I wanted to check my accuracy against a web site that showed the current sky. Was Saturn where I said it should be? As part of my Google search for such a web site planetarium, I came across a mention of Stellarium, a free open-source stargazing program for your computer. It looked pretty, and the fact that it was free made it a simple decision to install it and take a look at it. And lo and behold, it’s very good. Long ago I owned a copy of Red Shift from Maris, and it wasn’t a great experience. The interface was bulky and there was all kinds of weird content that I didn’t really need. Stellarium by contrast is very simple. Its interface feels a little Unix-y and text heavy (lots of single-letter accelerators that expert users can memorize), but it does exactly what I needed, it’s beautful, and it’s free.

As a professional software developer, this last part always gives me pause. I’ve lost count of the number of really useful really good programs I use that are completely free. Not ten minutes ago I downloaded the free Eclipse-based JavaScript/HTML editor Aptana along with a nice free font (Proggy Clean) to use with it. Last night I downloaded a free genealogy program called Personal Ancestral File. Again, it’s pretty basic, but it does exactly what I need. I don’t need and I don’t want to pay for all the fancy-pants features they cram into Family Tree Maker, another product I once spent money on.

Commercial vendors can charge for new features, but they must eventually run out of meaningful novelty. Their free competitors, who by definition can’t be run out of business, will ultimately swallow all features worth copying.
So I wonder: in the long run, will all software be free? I have become convinced that the answer is very nearly yes. In the long run, all software will be free, or hosted as a service, or both. Money will still pour through the system, but by a very different set of sluiceways.

Rube Goldberg is alive and well…

… and making videos in Japan.

Please, please don’t start this if you don’t have nine minutes to spare. This is the sort of thing where people usually say “This guy had WAY too much time on his hands.” But the commercial nature of these videos makes it clear that the creator was a pro. He’s getting paid to have that much time on his hands. Good for him, I say. We should all be so lucky.

Can’t… stop… watching…

If you can tear yourself away from the gadget videos, here’s a Rube Goldberg-ish Flash game. Ride down a doodle of your own design. Can you build a successful loop-the-loop track? Check it out: Line Rider by ~fsk on deviantART. (via tingelinde)

Molecular biology animations

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A few years ago, PBS ran a series called, simply, DNA. It included some of the spiciest, most inspiring animations of biological molecules in action that I’d ever seen. I longed to linger over them and savor them, but they came and went so fast in the show, and until this evening I had no idea who did the work. Over at information aesthetics I came across the 2006 infographics winners from Science magazine. One of these winners was Drew Berry of the Walter and Eliza Hall Institute in Melbourne, Australia. He’s the guy who made the beautiful animations.

Armed with this information, I was able to track down the mother lode in short order. Here is a page pointing to the QuickTime videos that gave me the shivers. May I particularly recommend the insane fruitbat circus otherwise known as DNA replication. If a Divine and Perfect Intellect is responsible the design of this unlikely contraption, somebody’s got a lotta ‘splainin’ to do.

Finally, here is an interview with Drew Berry about how he got the gig for the DNA TV series.

Cruel 2 B Kind: the friendly assassin

The game Assassin, as Wikipedia helpfully puts it, is a “live-action role playing game” where every player is trying to kill other players until only one remains. Unlike a card game or the round-the-table Werewolf game popular at Foo Camp, Assassin can span many days and include dozens of people. That means it collides with Real Life in fairly obvious ways. You can, for example, be killed on the way to class. But what does it mean to be killed? In one game you might be done in with a squirt gun, in another it might be a rubber band. But a new version of the game, as I learned at Collision Detection, involves killing with kindness.

Cruel 2 B Kind is a version of Assassin designed to get around one of the inconveniences of the game: freaking out bystanders with disturbing and apparently dangerous attack and evasion dramatics. Intead of murdering someone with a squirt gun, you do it with a targeted compliment. Thus, a badly-aimed volley will only brighten a bystander’s day rather than dampening their shirt or soiling their pants.

This all sounds clever to me, but I knew exactly where to go for the straight dope. At great expense, we have retained the services of Assassin Expert JMike and asked him for his opinion on the matter. When it comes to Assassin, JMike knows whereof he speaks. Over the past 15 years he has played and managed dozens of Assassin games great and small. Here’s what he had to say.

The “random act of kindness” shtick is a little sappy. Granted,
assassin-style games have always had a problem: how to arrange a game that
is played out in the real life urban jungle? People who design these kind
of games — well some of them anyway — fantasize about being able to set up
stake-outs, open-clandestine meetings, elaborate hits, etc. out in public,
but obviously you have this problem that the more realistic the setup, the
more likely it will be confused for the real thing (with dire consequences).
So the realism wing of the gaming world takes the action into controlled or
semi-controlled environments: college campuses, convention hotels, private
rural land, and they accept the necessary compromises: complex relationships
with the authorities and/or slightly watered-down action (paintball, boffer
weapons, very simplified role playing dynamics, etc.). This other wing of
the gaming world seems to be evolving recently, where they use VERY watered
down action in order to be able to play out in the real world. I’d say that
the recent movement of live performance art — I forget the name of the
phenomenon, but where you get like 200 people to meet and go up and down the
escalators in some iconic hotel lobby in town — is very closely related to
this wing of the gaming world. Anyway, I think modern technology is going
to be a big advance to this wing of the gaming world, in that you’ll be able
to do more complicated things where you get the thrill of the chase and
even, in a way, the thrill of the kill, without having to do things that
look dangerous or threatening to non-players.

SO I guess my take on it is that this is kind of a confluence of the old
school live-action role playing gaming scene with the
whatever-its-name-is-performance-art scene and more power to it. I hope and
expect to see some pretty good and funny things come out of it. Random act
of kindness warfare is a little bit of a sappy start though :)

So there you have it. One of my favorite things in life is knowing just who to ask when a certain topic comes up. You’d be surprised how often JMike is that person.

Voice recognition works now

I recently bought NaturallySpeaking, a program that does voice-to-text speech recognition. It’s owned by Nuance now, but the Dragon Systems technology has been bought and sold multiple times since work started on it in the 1980s. The latest versions (I bought Preferred version 9) have been getting consistently good reviews and I have a lot of text to enter, so I decided to take the plunge.

Sure enough, this software is almost disturbingly good. I picked up a book on alchemy that happened to be on my desk and read the following:

Standing between science and art, philosophy and religion, the mysterious practice of alchemy has long been cloaked in a veil of mystery. To this day, scholars are unsure of the precise origins of this esoteric craft, the forerunner of modern chemistry, which reached its peak in the Renaissance.

It didn’t make a single mistake in that passage.

As part of the training process for using the software they have you read one of several passages. I chose John F. Kennedy’s inaugural address. I was sorely tempted to read it in a funny John F. Kennedy voice, but the downside was obvious: I would have been obligated to speak in a funny John F. Kennedy voice every time I wanted to dictate something, and my fellow Americans, that is something that this administration cannot condone and will not support.

Some observations after using NaturallySpeaking for a few days: Even when dictation is 99.9% correct, you really want it to be 100% correct. I was also surprised to see just how much time I spend in editing, formatting, and fiddling with text, which is to say stuff that voice commands are not so good at. Voice is now good for laying down text in big blocks, but not so good at spatial fiddling. Even when you’re sitting next to a human who understands your words perfectly, it takes a lot of work for them to understand your intent. If you’re telling them how to use a GUI, you quickly end up in tech support hell, saying things like: “Double click on that. Not there… over there, just above that red thing. No, to the left! Farther left! Oh crap, you just launched Visual Studio. Here, give me the mouse.”

Another funny thing is that since the contextual understanding is so good these days, the errors that you do get are harder to spot in a quick proofing pass. In a world of clever machines, be grateful for obvious miss steaks. Ha ha. Just kitten.